解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Depression is a common non-motor symptom in patients with Parkinson's disease (PD) and difficult to treat. Crocin is a natural multipotential neuroprotective compound that has been shown to elicit antidepressant activity and is promising for the therapy of neuropsychological diseases. Here, we investigated the therape...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-01941-2
更新日期:2020-07-01 00:00:00
abstract::Prion replication results from the autocatalytic templated assisted conversion of the host-encoded prion protein PrPC into misfolded, polydisperse PrPSc conformers. Structurally distinct PrPSc conformers can give rise to multiple prion strains. Within and between prion strains, the biological activity (replicative eff...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-01897-3
更新日期:2020-06-01 00:00:00
abstract::In human glioma tumours, heme oxygenase-1 (HO-1) is overexpressed when compared with normal brain tissues and during oligodendroglioma progression. However, the molecular mechanisms mediated by HO-1 to promote glioblastoma remain unknown. We therefore aimed at investigating the effect of HO-1 expression and its select...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-01869-7
更新日期:2020-05-01 00:00:00
abstract::Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with unknown etiology. Recent experimental evidences suggest the contribution of non-coding RNAs (ncRNAs) in the pathophysiology of ASD. In this work, we aimed to investigate the expression profile of the ncRNA class of circular RNAs (circR...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-01878-6
更新日期:2020-05-01 00:00:00
abstract::Hypoxic-ischemic (HI) brain injury remains an important cause of brain damage in neonates with potential life-long consequences. Caffeine, which is a competitive inhibitor of adenosine receptors, is commonly used as treatment for preterm apnoea in clinical settings. In the current study, we investigated the effects of...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-01867-9
更新日期:2020-05-01 00:00:00
abstract::The retina is an extension of the central nervous system and has been considered to be a simplified, more tractable and accessible version of the brain for a variety of neuroscience investigations. The optic nerve displays changes in response to underlying neurodegenerative diseases, such as stroke, multiple sclerosis...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-019-01863-8
更新日期:2020-04-01 00:00:00
abstract::Epigallocatechin-3-gallate (EGCG), a catechin found in green tea, has been previously investigated for its neuroprotective effects in vitro and in vivo. In the present study, we aimed to evaluate its possible beneficial effects in a well-established preclinical mixed model of familial Alzheimer's disease (AD) and type...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01849-6
更新日期:2020-04-01 00:00:00
abstract::The transition from occasional to escalated psychostimulant use is accelerated by prior drug exposure. These behavioral observations may be related to long-lasting transcriptional and/or epigenetic changes induced by the drug pre-exposure. Herein, we investigated if a single methamphetamine (METH) injection would enha...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01830-3
更新日期:2020-03-01 00:00:00
abstract::A growing body of evidence indicates that pathological forms of amyloid beta (Aβ) peptide contribute to neuronal degeneration and synaptic loss in Alzheimer's disease (AD). In this study, we investigated the impact of exogenous Aβ1-42 oligomers (AβO) and endogenously liberated Aβ peptides on transcription of genes for...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01819-y
更新日期:2020-03-01 00:00:00
abstract::Autism spectrum disorders (ASD) comprise a complex of neurodevelopmental disorders caused by a variety of genetic defects and characterized by alterations in social communication and repetitive behavior. Since the mechanisms leading to early neuronal degeneration remain elusive, we chose to examine the properties of N...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01811-6
更新日期:2020-03-01 00:00:00
abstract::TREK-1, a two-pore-domain K+ channel, is highly expressed in the central nervous system. Although aberrant expression of TREK-1 is implicated in cognitive impairment, the cellular and functional mechanism underlying this channelopathy is poorly understood. Here we examined TREK-1 contribution to neuronal morphology, e...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01828-x
更新日期:2020-03-01 00:00:00
abstract::Removal of the Bax gene from mice completely protects the somas of retinal ganglion cells (RGCs) from apoptosis following optic nerve injury. This makes BAX a promising therapeutic target to prevent neurodegeneration. In this study, Bax+/- mice were used to test the hypothesis that lowering the quantity of BAX in RGCs...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01783-7
更新日期:2020-02-01 00:00:00
abstract::The human KCTD13 gene is located within the 16p11.2 locus and copy number variants of this locus are associated with a high risk for neuropsychiatric diseases including autism spectrum disorder and schizophrenia. Studies in zebrafish point to a role of KCTD13 in proliferation of neural precursor cells which may contri...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01727-1
更新日期:2020-02-01 00:00:00
abstract::Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are essential for monitoring the physical and chemical environment of the airways and lungs. Subtypes are heterogenous in their responsiveness to stimuli, phenotype, and developmental origin, but they collectively serve to regulate normal ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01782-8
更新日期:2020-02-01 00:00:00
abstract::Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) exhibits neuropathological and immunological dysfunctions similar to those found in multiple sclerosis (MS) and has been used as an animal model of MS. Inflammatory infiltrates and oxidative stress have been linked to the development of both diseases. ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01774-8
更新日期:2020-02-01 00:00:00
abstract::Parkinson's disease (PD) is a highly prevalent neurodegenerative disease for which no disease-modifying treatments are available, mainly because knowledge about its pathogenic mechanism is still incomplete. Recently, a key role for lipids emerged, but lipid profiling of brain samples from human subjects is demanding. ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01733-3
更新日期:2020-02-01 00:00:00
abstract::Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-month-old male tau kn...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01722-6
更新日期:2020-01-01 00:00:00
abstract::Neurons with a desired neurotransmitter phenotype can be differentiated from induced pluripotent stem cells or from somatic cells only through tedious protocols with relatively low yield. Readily available cortical neurons isolated from embryonic rat brain, which have already undergone a complete neuronal differentiat...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01701-x
更新日期:2020-01-01 00:00:00
abstract::Although the pathogenesis of Alzheimer's disease (AD) remains unclear, some molecular aspects that precede or accompany the deposit of β-amyloid in senile plaques attract attention, such as calcium dysregulation and neuroinflammation. It has been suggested that the Ca2+/calmodulin-dependent protein phosphatase, calcin...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01718-2
更新日期:2020-01-01 00:00:00
abstract::Enriched environment (EE) protects the retina from adult rats against ischemia/reperfusion (I/R) injury; however, how the components of EE contribute to the recovery after retinal ischemic damage remains unclear. We analyzed the contribution of social, cognitive, and visual stimulation on functional and histological a...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01715-5
更新日期:2020-01-01 00:00:00
abstract::Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with varied prognosis, chronic course, and duration of illness with reduced quality of life. One factor that significantly contributes to the relevant disease burden of MDD is the heterogeneous treatment response patients experience with cu...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-019-01670-1
更新日期:2019-12-01 00:00:00
abstract::Although in-hospital mortality rates for sepsis have decreased, survivors often experience lasting physical and cognitive deficits. Moreover, older adults are more vulnerable to long-term complications associated with sepsis. We employed a murine model to examine the influence of age and sex on the brain's response an...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01681-y
更新日期:2019-12-01 00:00:00
abstract::Late-onset Alzheimer's disease (LOAD) is a high-occurrence neurological disorder but the difficulty in identifying precise and early biomarkers has complicated the understanding of the disease and the development of new treatments. In this sense, important knowledge is emerging regarding novel molecular and biological...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01676-9
更新日期:2019-12-01 00:00:00
abstract::Depression is the leading cause of disability worldwide with global distribution of 322 million people suffering from the disease. While much is understood about depression, the underlying pathophysiology is yet to be fully characterized. Recently, the unfolded protein response (UPR) has been shown to be involved in r...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01687-6
更新日期:2019-12-01 00:00:00
abstract::Beginning in the early stages of Alzheimer's disease (AD), the hippocampus reduces its functional connections to other cortical regions due to synaptic depletion. However, little is known regarding connectivity abnormalities within the hippocampus. Here, we describe rostral-caudal hippocampal convergence (rcHC), a met...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01671-0
更新日期:2019-12-01 00:00:00
abstract::This study examined the effects of pinealectomy in Wistar rats and melatonin replacement therapy on the daily mRNA expression of melatonin (Tph1, Aanat, Asmt, Mt1, Mt2, and Rorα), and steroidogenic (Star, 17βhsd3, and Lhr) related genes as well as clock genes (Rev-erbα, Bmal1, Per1, Per2, Cry1, and Cry2) in testes. Th...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1626-y
更新日期:2019-11-01 00:00:00
abstract::Although neurons in the adult mammalian CNS are inherently incapable of regeneration after injury, we previously showed that exogenous delivery of pigment epithelium-derived factor (PEDF), a 50-kDa neurotrophic factor (NTF), promoted adult retinal ganglion cell neuroprotection and axon regeneration. Here, we show that...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1614-2
更新日期:2019-11-01 00:00:00
abstract::The Shadoo protein (Sho) exhibits homology to the hydrophobic region of the cellular isoform of prion protein (PrPC). As prion-infected brains gradually accumulate infectivity-associated isoforms of prion protein (PrPSc), levels of mature endogenous Sho become reduced. To study the regulatory effect of the proteostati...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1623-1
更新日期:2019-11-01 00:00:00
abstract::Beta-amyloid (Aβ) in the brain is a key pathological feature of certain neurodegenerative diseases. Recent studies using graph theory have shown that Aβ brain networks are of pathological significance in Alzheimer's disease (AD). However, the characteristics of Aβ brain networks in Parkinson's disease (PD) are unknown...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1625-z
更新日期:2019-11-01 00:00:00
abstract::The connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1596-0
更新日期:2019-11-01 00:00:00
abstract::Sphingosine-1-phosphate (S1P) produced by sphingosine kinases (SPHK1 and SPHK2) is a signaling molecule involved in cell proliferation and formation of cellular junctions. In this study, we characterized the retinas of Sphk1 knockout (KO) mice by electron microscopy and immunocytochemistry. We also tested cultured Mül...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1599-x
更新日期:2019-10-01 00:00:00
abstract::A disintegrin and metalloproteinase 10 (ADAM10) is a synaptic enzyme that has been previously shown to limit amyloid-β1-42 (Aβ1-42) peptide formation in Alzheimer's disease (AD). Furthermore, ADAM10 participates to spine shaping through the cleavage of adhesion molecules and its activity is under the control of synapt...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1583-5
更新日期:2019-10-01 00:00:00
abstract::Specific variations in the amino acid sequence of prion protein (PrP) are key determinants of susceptibility to prion diseases. We previously showed that an amino acid substitution specific to canids confers resistance to prion diseases when expressed in mice and demonstrated its dominant-negative protective effect ag...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1535-0
更新日期:2019-09-01 00:00:00
abstract::The melanocortin pathway has been implicated in both metabolism and sexual function. When the melanocortin 4 receptor (MC4R) is knocked out globally, male mice display obesity, low sexual desire, and copulatory difficulties; however, it is unclear whether these phenotypes are interdependent. To elucidate the neuronal ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1514-5
更新日期:2019-09-01 00:00:00
abstract::The ability of pluripotent stem cells (PSCs) to differentiate into retinal tissue has led to many attempts to direct this process to yield specific retinal cell types. The ability to do so would greatly impact both the study of normal retina development in model systems that can be precisely controlled and the generat...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-019-1504-7
更新日期:2019-09-01 00:00:00
abstract::Cultured hippocampal neurons represent the most widely used experimental substrate for in vitro electrophysiological studies. Nevertheless, in most cases, the nature of neuron under study is not identified as excitatory or inhibitory, or even worse, recorded neurons are considered as excitatory because of the paucity ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1506-5
更新日期:2019-09-01 00:00:00
abstract::Fatty acid-binding proteins (FABPs) bind and internalize long-chain fatty acids, controlling lipid dynamics. Recent studies have proposed the involvement of FABPs, particularly FABP7, in lipid droplet (LD) formation in glioma, but the physiological significance of LDs is poorly understood. In this study, we sought to ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1489-2
更新日期:2019-08-01 00:00:00
abstract::Evidence indicates that adverse experiences in early life may be a factor for immune disturbances leading to the depression in adulthood. Recently, a pivotal role in the pathogenesis of depression has been assigned to the activation of the brain Nod-like receptor pyrin-containing 3 (NLRP3) inflammasome. We investigate...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1458-1
更新日期:2019-08-01 00:00:00
abstract::Autism and epilepsy are diseases which have complex genetic inheritance. Genome-wide association and other genetic studies have implicated at least 500+ genes associated with the occurrence of autism spectrum disorders (ASD) including the human semaphorin 3F (Sema 3F) and neuropilin 2 (NRP2) genes. However, the geneti...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1450-9
更新日期:2019-08-01 00:00:00
abstract::Findings from observational and experimental studies suggest that maternal inflammation during pregnancy is associated with autism spectrum disorder (ASD). We report the first study in humans to examine this association in a large prospective birth cohort. We studied 788 mother-child pairs from the Seychelles Child De...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1424-y
更新日期:2019-07-01 00:00:00